Block Facebook Ads and simplify the interface with Facebook Neue
You can block all the Facebook ads and reskin the site into a more simplistic interface (similar to Twitter really) by installing a third party browser extension called Facebook Neue. Along with blocking the sites ads, it moves the UI into a two column layout, hides a few of the sidebar options, removes application links and language settings, and even rounds image avatars, creating a more simplified and less busy interface for the popular social networking site.
The Facebook Neue extension is available for Safari 5 and Chrome, you can download it here.
You might want to check out the Facebook desktop notifier too, it brings Facebook messages and activity to your Mac desktop through Growl notifications.